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Diet & Health : Cancer Last Updated: Apr 20, 2011 - 9:38:09 AM

Grapes may be used to prevent breast cancer
By Ben Wasserman
Aug 12, 2007 - 7:45:46 PM

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Sunday August 12, 2007 ( -- A new study published in the June 10 issue of Journal of Medicinal Foods suggests that drinking Concord grape juice may help prevent cancer-causing agents from causing DNA mutations that would otherwise lead to development of breast cancer.


The study conducted by Singletary K W, Jung K J and Giusti M from the University of Illinois at Urbana-Champaign meant to test the effect of anthocyanins found rich in concord grapes for their potential to inhibit NDA adduct formation induced by an environmental carcinogen known as benzo(a)pyrene.


In the study, an anthocyanin-rich extract from Concord grapes or Concord grape extract (CGE) at 10 and 20 microgram per milliliter and delphinidin, a component of grape extract at 0.6 micromole concentrations were applied to MCF-10F cells, a noncancerous, immortalized human breast epithelial cell line.


The researchers found the components at these doses significantly inhibited BP-DNA adduct formation.    These grape components were also found to suppress reactive oxygen species formation.


The inhibition of BP-DNA adduct formation was associated with a significant increase in activities of the phase II detoxification enzymes glutathione S-transferase and NAD(P)H:quinone reductase 1, the study shows.


Singletary and colleagues conclude that "CGE and a component grape anthocyanin have breast cancer chemopreventive potential due in part to their capacity to block carcinogen-DNA adduct formation, modulate activities of carcinogen-metabolizing enzymes, and suppress ROS in these noncancerous human breast cells."


Similar studies show components such as proanthocyanadin extract from grape seed significantly suppressed carcinogenesis of MCF10A cells induced by environmental toxins such as the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. One such study was conducted by Wang HC and colleagues from the University of Tennessee and published in the July 26 issue of Breast Cancer Research and Treatment.


One study by Chen S and colleagues from Beckman Institute of the City of Hope and Duarte, California shows the grape seed extract rich in procyanidin dimmers inhibits both expression and activity of aromatase, an enzyme that converts androgen to estrogen and promotes growth of hormone-dependent breast cancer.   The study was published in the June 1, 2006 issue of Cancer Research.




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