Vitami.n C lowers bloo.d pressur.e
Harakeh and R. J. Jariwalla at Linus Pauling Institute of Science and Medicine
in Palo Alto, CA has done quite some research on the inhibitory effect of
vitamin C on HIV replication and found that this
vitamin along with other
reducing agents may be used as a treatment to reduce the virus titer.
a report published in the Dec 1991 issue of American Journal of Clinical
Nutrition, Harakeh and Jariwalla said they tested calcium ascorbate, a salt of vitamin C, and two
thiol-based reducing agents (glutathione and N-acetyl-L-cysteine (NAC)) for their
effect against the
virus HIV-1 replication in
chronically infected T lymphocytes.
found that calcium ascorbate has the same magnitude of effect at reducing
extracellular HIV reverse transcriptase as ascorbic acid or vitamin C does. But
chronic exposure to ascorbate was necessary for HIV suppression.
NAC, but not glutathione caused less than
twofold inhibition of HIV reverse transcriptase and rendered a synergistic
effect (about 8-fold inhibition) when tested together with vitamin C.
in 1994, the researchers published another study in the June 1994 issue of Chem
Biol Interact saying that "the activity of an HIV LTR-directed reporter
protein made in ascorbate-treated cells was reduced to approximately 11%
relative to that of untreated control," indicating that vitamin C
"exerts a posttranslational inhibitory effect on HIV by causing impairment
of enzymatic activity."
1995, Harakeh and Jariwalla reported in the Sep-Oct issue of Nutrition that
"exposure to 300 micrograms/ml ascorbate (vitamin C in the form of salt) resulted in approximately 5- to
10-fold lowering of the extra-cellular RT (reverse transcriptase) titer. In
contrast, no significant suppression in extracellular RT levels was seen with
concentrations of AZT (an antiviral drug) in the range of 1-5
micrograms/ml." (By David Liu)