Table of Contents

I. Introduction

II. Carcinogens Listed in the Eleventh Report

A. Known to be Human Carcinogens
B. Reasonably Anticipated to be Human Carcinogens

III. Substance Profiles

Acetaldehyde
2-Acetylaminofluorene
Acrylamide
Acrylonitrile
Adriamycin^® (Doxorubicin Hydrochloride)
Aflatoxins
Alcoholic Beverage Consumption
2-Aminoanthraquinone
o-Aminoazotoluene
4-Aminobiphenyl
1-Amino-2,4-dibromoanthraquinone
1-Amino-2-methylanthraquinone
Amitrole
o-Anisidine Hydrochloride
Arsenic Compounds, Inorganic
Asbestos
Azacitidine
Azathioprine
Benzene
Benzidine and Dyes Metabolized to Benzidine
Benzidine
Dyes Metabolized to Benzidine
Benzotrichloride
Beryllium and Beryllium Compounds
Bromodichloromethane
2,2-bis(Bromomethyl)-1,3-propanediol (Technical Grade)
1,3-Butadiene
1,4-Butanediol Dimethylsulfonate (Myleran^®)
Butylated Hydroxyanisole (BHA)
Cadmium and Cadmium Compounds
Carbon Tetrachloride
Ceramic Fibers (Respirable Size)
Chlorambucil
Chloramphenicol
Chlorendic Acid
Chlorinated Paraffins (C₁₂, 60% Chlorine)
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea
bis(Chloroethyl) Nitrosourea
Chloroform
bis(Chloromethyl) Ether and Technical-Grade Chloromethyl Methyl Ether
3-Chloro-2-methylpropene
4-Chloro- o-phenylenediamine
Chloroprene
p-Chloro- o-toluidine and p-Chloro- o-toluidine Hydrochloride
Chlorozotocin
Chromium Hexavalent Compounds
C.I. Basic Red 9 Monohydrochloride
Cisplatin
Coal Tars and Coal Tar Pitches
Cobalt Sulfate
Coke Oven Emissions
p-Cresidine
Cupferron
Cyclophosphamide
Cyclosporin A
Dacarbazine
Danthron (1,8-Dihydroxyanthraquinone)
2,4-Diaminoanisole Sulfate
2,4-Diaminotoluene
Diazoaminobenzene
1,2-Dibromo-3-chloropropane
1,2-Dibromoethane (Ethylene Dibromide)
2,3-Dibromo-1-propanol
tris(2,3-Dibromopropyl) Phosphate
1,4-Dichlorobenzene
3,3´-Dichlorobenzidine and 3,3´-Dichlorobenzidine Dihydrochloride
Dichlorodiphenyltrichloroethane (DDT)
1,2-Dichloroethane (Ethylene Dichloride)
Dichloromethane (Methylene Chloride)
1,3-Dichloropropene (Technical Grade)
Diepoxybutane
Diesel Exhaust Particulates
Diethyl Sulfate
Diethylstilbestrol
Diglycidyl Resorcinol Ether
3,3´-Dimethoxybenzidine and Dyes Metabolized to 3,3´-Dimethoxybenzidine
3,3´-Dimethoxybenzidine
Dyes Metabolized to 3,3´-Dimethoxybenzidine
4-Dimethylaminoazobenzene
3,3´-Dimethylbenzidine and Dyes Metabolized to 3,3´-Dimethylbenzidine
3,3´-Dimethylbenzidine
Dyes Metabolized to 3,3´-Dimethylbenzidine
Dimethylcarbamoyl Chloride
1,1-Dimethylhydrazine
Dimethyl Sulfate
Dimethylvinyl Chloride
1,4-Dioxane
Disperse Blue 1
Epichlorohydrin
Erionite
Estrogens, Steroidal
Ethylene Oxide
Ethylene Thiourea
di(2-Ethylhexyl) Phthalate
Ethyl Methanesulfonate
Formaldehyde (Gas)
Furan
Glass Wool (Respirable Size)
Glycidol
Hepatitis B
Hepatitis C
Heterocyclic Amines
2-Amino-3,4-dimethylimidazo[4,5- f]quinoline (MEIQ)
2-Amino-3,8-dimethylimidazo[4,5- f]quinoxaline (MEIQx)
2-Amino-3-methylimidazo[4,5- f]quinoline (IQ)
2-Amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP)
Hexachlorobenzene
Hexachloroethane
Hexamethylphosphoramide
Human Papillomaviruses: Some Genital-Mucosal Types
Hydrazine and Hydrazine Sulfate
Hydrazobenzene
Ionizing Radiation
X-Radiation and Gamma Radiation
Neutrons
Radon
Thorium Dioxide
Iron Dextran Complex
Isoprene
Kepone^® (Chlordecone)
Lead and Lead Compounds
Lindane and Other Hexachlorocyclohexane Isomers
Melphalan
Methoxsalen with Ultraviolet A Therapy (PUVA)
2-Methylaziridine (Propylenimine)
4,4´-Methylenebis(2-chloroaniline)
4,4´-Methylenebis( N,N-dimethyl)benzenamine
4,4´-Methylenedianiline and its Dihydrochloride Salt
Methyleugenol
Methyl Methanesulfonate
N-Methyl- N´-nitro- N-nitrosoguanidine
Metronidazole
Michler's Ketone (4,4'-(Dimethylamino)benzophenone)
Mineral Oils (Untreated and Mildly Treated)
Mirex
Mustard Gas
Naphthalene
2-Naphthylamine
Nickel Compounds and Metallic Nickel
Nickel Compounds
Metallic Nickel
Nitrilotriacetic Acid
o-Nitroanisole
Nitroarenes (selected)
1,6-Dinitropyrene
1,8-Dinitropyrene
6-Nitrochrysene
1-Nitropyrene
4-Nitropyrene
Nitrobenzene
Nitrofen (2,4-Dichlorophenyl- p-nitrophenyl Ether)
Nitrogen Mustard Hydrochloride
Nitromethane
2-Nitropropane
N-Nitrosodi- n-butylamine
N-Nitrosodiethanolamine
N-Nitrosodiethylamine
N-Nitrosodimethylamine
N-Nitrosodi- n-propylamine
N-Nitroso- N-ethylurea
4-( N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
N-Nitroso- N-methylurea
N-Nitrosomethylvinylamine
N-Nitrosomorpholine
N-Nitrosonornicotine
N-Nitrosopiperidine
N-Nitrosopyrrolidine
N-Nitrososarcosine
Norethisterone
Ochratoxin A
4,4´-Oxydianiline
Oxymetholone
Phenacetin and Analgesic Mixtures Containing Phenacetin
Phenacetin
Analgesic Mixtures Containing Phenacetin
Phenazopyridine Hydrochloride
Phenolphthalein
Phenoxybenzamine Hydrochloride
Phenytoin
Polybrominated Biphenyls (PBBs)
Polychlorinated Biphenyls (PCBs)
Polycyclic Aromatic Hydrocarbons, 15 Listings
Benz[ a]anthracene
Benzo[ b]fluoranthene
Benzo[ j]fluoranthene
Benzo[ k]fluoranthene
Benzo[ a]pyrene
Dibenz[ a,h]acridine
Dibenz[ a,j]acridine
Dibenz[ a,h]anthracene
7 H-Dibenzo[ c,g]carbazole
Dibenzo[ a,e]pyrene
Dibenzo[ a,h]pyrene
Dibenzo[ a,i]pyrene
Dibenzo[ a,l]pyrene
Indeno[1,2,3- cd]pyrene
5-Methylchrysene
Procarbazine Hydrochloride
Progesterone
1,3-Propane Sultone
ß-Propiolactone
Propylene Oxide
Propylthiouracil
Reserpine
Safrole
Selenium Sulfide
Silica, Crystalline (Respirable Size)
Soots
Streptozotocin
Strong Inorganic Acid Mists Containing Sulfuric Acid
Styrene-7,8-oxide
Sulfallate
Tamoxifen
2,3,7,8-Tetrachlorodibenzo- p-dioxin (TCDD); "Dioxin"
Tetrachloroethylene (Perchloroethylene)
Tetrafluoroethylene
Tetranitromethane
Thioacetamide
4,4´-Thiodianiline
Thiotepa
Thiourea
Tobacco Related Exposures
Environmental Tobacco Smoke
Smokeless Tobacco
Tobacco Smoking
Toluene Diisocyanate
o-Toluidine and o-Toluidine Hydrochloride
Toxaphene
Trichloroethylene
2,4,6-Trichlorophenol
1,2,3-Trichloropropane
Ultraviolet Radiation Related Exposures
Solar Radiation
Sunlamps or Sunbeds, Exposure to
Broad-Spectrum Ultraviolet (UV) Radiation
Ultraviolet A Radiation
Ultraviolet B Radiation
Ultraviolet C Radiation
Urethane
Vinyl Bromide
Vinyl Chloride
4-Vinyl-1-cyclohexene Diepoxide
Vinyl Fluoride
Wood Dust

IV. Tables

Table 1.Chemicals Nominated to the NTP for In-Depth Toxicological Evaluation or Carcinogenesis Testing in Fiscal Years 1988-2001

Table 2.CDC/NIOSH Response to Inquiries about Carcinogens Listed in the Eleventh Report on Carcinogens

V. Report on Carcinogens Nomination Review Procedures

Appendices

A. Manufacturing Processes, Occupations, and Exposure Circumstances Classified by IARC as Category 1, Carcinogenic to Humans

B. Agents, Substances, Mixtures, or Exposure Circumstances Delisted from the Report on Carcinogens

C. Agents, Substances, Mixtures, or Exposure Circumstances Reviewed but not Recommended for Listing in the Report on Carcinogens

D. List of Participants

E. Glossary

F. Acronyms and Abbreviations

G. Units of Measurement

Indexes

A. Names and Synonyms used in RoC Substance Profiles

B. CAS Registry Numbers