Sep 20, 2008 (foodconsumer.org) -- A new Italian study shows that about half
overweight people with stage 1 hypertension or high blood pressure can get
their blood pressure normalized by simply losing 5 to 12 percent weight and
normalizing their body mass index.
study was conducted by Roberto Fogari and colleagues at Universita` di Pavia in
Pavia, Italy and presented at the 62nd High Blood Pressure Research Conference
2008 in Atlanta, GA.
study was meant to evaluate the role of weight loss on blood pressure values in
overweight people with stage 1 hypertension who never received any medications
to treat their hypertensive condition.
study involved 189 overweight people (BMI 25 to 29.9 kg/m2) with stage 1
hypertensive outpatients (systolic blood pressure or SBP=140-159 mmHg and diastolic
blood pressure or DBP 90 - 99mmHg). The participants were given dietary advice
and or 120 to 360 mg of Orlistat per day to achieve a 5-percent-loss in the
body weight in 6 months.
who successfully lost the targeted 5 percent body weight continued the
treatment for another 6 months and blood pressure and body weight were measured
At baseline, 6 and 12
months of the treatment, 24-hour ambulatory blood pressure was evaluated and blood
samples were drawn to test plasma leptin, active renin and aldosterone.
researchers found 111 participants or 59 percent of the study subjects achieved
5 percent reduction in their body weight.
found that those who lost the targeted amount of body weight experienced a significant
drop in SBP and DBP (-6.9 and -4.2 percent respectively) and high weight loss resulted
in high reduction in blood pressure.
addition, those who lost 5 percent of the body weight also experienced a
reduction in plasma leptin, active renin and aldosterone.
those who achieved 5 percent loss in the body weight, fifty three or 48 percent
normalized their BMI and 28 of them or 53 percent normalized their blood
pressure. The levels of leptin, renin and aldosterone in the 28 people who
normalized their blood pressure are not different from those of the remaining
study presented also at the American Heart Association's Fall Conference of the
Council for High Blood Pressure Research, in Atlanta shows too much dietary
salt can contribute to resistant high blood pressure.
hypertension refers to a condition where blood pressure remains above the
target level even when three medications are used in an effort to lower
High blood pressure is also called
resistant to treatment if the condition can only get controlled by taking four
or more medications.
study led by the University of Alabama researchers involved 13 patients with
resistant high blood pressure. Participants were assigned to a high or low salt
diet and all of them were taking at least three blood pressure medications.
researchers found those assigned the low-salt diet reduced their systolic blood
pressure by 22.6 percent and diastolic blood pressure by 9.2 percent compared
to those who were assigned to the high-salt diet.
Japanese study also presented at the conference showed that high salt diet can
exacerbate hypertension via an increase in oxidative stress.
sodium intake, above 2,300 milligrams daily, should be avoided in all patients
with hypertension, and among those patients with medically resistant
hypertension, a closely monitored low-salt diet [1,500 milligrams daily] should
be considered," Dr. Gregg C. Fonarow, a professor of cardiology at the
University of California, Los Angeles was quoted by healthday.com as saying.
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