From foodconsumer.org
Grape seed extract may help prevent Alzheimer's
By Ben Wasserman
Jun 29, 2008 - 10:10:13 AM
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SUNDAY June 29, 2008 (foodconsumer.org) -- A study conducted by Wang J and colleagues from Mount Sinai School of Medicine in New York suggests that taking grape seed extract supplements may help prevent or even treat Alzheimer's disease.
The study published on June 18 in the Journal of Neuroscience showed that grape see polyphenolic extract significantly inhibits amyloid beta-protein aggregation into high molecular weight oligomers in vitro.
The study also showed that when orally administered to lab mice, the extract dramatically attenuates cognitive deterioration commonly experienced by Alzheimer's patients.
Alzheimer's disease is a neurodegenerative disease characterized by progressive impairments in memory and cognition. There is no cure for the disease.
Extracellular accumulation of soluble high-molecular-weight oligomers has been proposed to be responsible for Alzheimer's dementia and memory deficits in mice with an disorder similar to human Alzheimer’s disease.