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Diet & Health : General Health Last Updated: Apr 20, 2011 - 9:38:09 AM

High fat, high fructose may damage the liver quickly
By Ben Wasserman
Mar 17, 2008 - 1:44:30 PM

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MONDAY March 17, 2008 ( -- A new study suggests that a diet with high fat and high fructose corn syrup may cause severe liver damage in people with a sedentary lifestyle, reported.

The study conducted by researchers from Saint Louis University and scheduled to be presented this year at the Digestive Diseases Week meeting in Washington D.C. found it took as short as four weeks for animals to show the first signs of serious health problems.

In the study, the researchers fed mice a diet with 40 percent fat and a high amount of high fructose corn syrup for 16 weeks.  Mice were allowed to eat whatever amounts of food they wanted, but not allowed to exercise.

The amount of high fructose corn syrup was equivalent to eight cans of soda a day in a human diet while the amount fat was about the same found in a typical McDonald's meal; cited Brent Tetri M.D. at Saint Louis University as saying.

Tetri said "It took only four weeks for liver enzymes to increase and for glucose intolerance -- the beginning of Type 2 diabetes -- to begin."

The problem with tested diet may be that fructose suppresses the body's feeling of fullness, meaning that the mice on the diet did not know when they were supposed to stop, Tetri cited preliminary research to suggest.

"A high-fat and sugar-sweetened diet compounded by a sedentary lifestyle will have severe repercussions for your liver and other vital organs," Tetri cautioned, quoted by

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