Foodconsumer.org

 
USCards.com Bookmark Us
All Food, Diet and Health News 
 
 Misc. News
 Must-Read News
 Letter to Editor
 Featured Products
 Recalls & Alerts
 Consumer Affair
 Non-food Things
 Health Tips
 Interesting Sites
 
 Diet & Health
 Heart & Blood
 Cancer
 Body Weight
 Children & Women
 General Health
 Nutrition
 
 Food & Health
 Food Chemicals
 Biological Agents
 Cooking & Packing
 Technologies
 Agri. & Environ.
 Laws & Politics
 
 General Health
 Drug News
 Diseases
 Mental Health
 Infectious Disease
 Environment
 Lifestyle
 Government
 Other News
 
 Food Consumer
 FC News & Others
Search





Search Foodconsumer & Others


Add to Google
Add to My Yahoo
Newsfeed

foodconsumer.org news feed
Su bmit news[release]



More than 100 credit cards available at uscards.com from uscards.com, you can pick more than 100 credit cards


Diet & Health : General Health Last Updated: Apr 20, 2011 - 9:38:09 AM


Of mice and peanuts, a new mouse model for peanut allergy
By news release
Jan 12, 2009 - 4:52:23 PM

E.mail t.his a.rticle
 P.rinter f.riendly p.age
Get n.ewsletter
 
   
U.S. Department of Health and Human Services
NATIONAL INSTITUTES OF HEALTH NIH News
National Institute of Allergy and Infectious Diseases (NIAID) <http://www.niaid.nih.gov/>
For Immediate Release: Monday, January 12, 2009

CONTACT: Julie Wu, 301-402-1663, <e-mail: wujuli@niaid.nih.gov>

OF MICE AND PEANUTS: A NEW MOUSE MODEL FOR PEANUT ALLERGY

Chicago researchers report the development of a new mouse model for food allergy that mimics symptoms generated during a human allergic reaction to peanuts. The animal model provides a new research tool that will be invaluable in furthering the understanding of the causes of peanut and other food allergies and in finding new ways to treat and prevent their occurrence, according to experts at the National Institute of Allergy and Infectious Diseases (NIAID), the component of the National Institutes of Health (NIH) that funded the research. Peanut allergy is of great public health interest because this food allergy is the one most often associated with life-threatening allergic reactions, resulting in up to 100 deaths in the United States each year.

The findings of the research team, led by Paul Bryce, Ph.D., of the Feinberg School of Medicine at Northwestern University, appear in the January issue of the Journal of Allergy and Clinical Immunology. The development of new animal models for food allergy was identified as a critical need by the 2006 NIH Expert Panel on Food Allergy Research.

"Food allergies affect the health and quality of life of many Americans, particularly young children," says NIAID Director Anthony S. Fauci, M.D. "Finding an animal model that mimics a severe human allergic reaction to peanuts will help us better understand peanut allergy and develop new and improved treatment and prevention strategies."

Allergic reactions to food can range from mild hives to vomiting to difficulty breathing to anaphylaxis, the most severe reaction. Anaphylaxis may result from a whole-body allergic reaction to the release of the chemical histamine, causing muscles to contract, blood vessels to dilate and fluid to leak from the bloodstream into the tissues. These effects can result in narrowing of the upper or lower airways, low blood pressure, shock or a combination of these symptoms, and also can lead to a loss of consciousness and even death.

The most significant obstacle to developing an animal model of food allergy is that animals are not normally allergic to food. Scientists must add a strong immune stimulant to foods to elicit a reaction in animals that resembles food allergy in humans. Because of this requirement, useful animal models have been developed only in the last few years, and such animal models have until now used cholera toxin as the immune stimulant.

Dr. Bryce's team took the novel approach of feeding mice a mixture of whole peanut extract (WPE) and a toxin from the bacteria Staphylococcus aureus, called staphylococcal enterotoxin B (SEB) to simulate the human anaphylactic reaction to peanuts in mice.


"Persistent S. aureus colonization is commonly found on the skin of people with eczema and in the nasal cavities of people with sinusitis," says Dr. Bryce. "The history between S. aureus and allergic diseases led us to use staphylococcal toxins to stimulate food allergy in animals."

According to Dr. Bryce, the results using the SEB/WPE mixture were considerably better than those seen with previous animal models, which failed to mimic many features of food allergy.  They showed that the SEB/WPE mixture stimulated severe symptoms in mice that closely resemble those found in human anaphylaxis, including swelling around the eyes and mouth, reduced movement and significant problems breathing. Additionally, mice given the SEB/WPE mixture had high blood levels of histamine, which indicates a severe allergic reaction.

The researchers also observed that the blood and tissues of mice in the SEB/WPE group had higher-than-normal numbers of eosinophils, which are white blood cells often associated with allergy-related inflammation. Future studies will be needed to determine if eosinophils play an important role in human food allergy.

These results, say Dr. Bryce, suggest that this animal model of food allergy will be useful for many types of future research studies.

Approximately 4 percent of Americans have food allergies.  For reasons that are not well understood, the prevalence in children increased by 18 percent between 1997 and 2007. The most common causes of food allergies are milk, eggs, shellfish, peanuts, tree nuts, wheat and soy.

Each year there are between 15,000 and 30,000 episodes of food-induced anaphylaxis, which are associated with 100 to 200 deaths in the United States.

NIAID is the lead institute at NIH for research in food allergy and supports basic research in allergy and immunology to understand how foods trigger an allergic reaction.  NIAID also conducts clinical trials that are attempting to alter the body's immune response so that it does not trigger allergic reactions to food.

NIAID conducts and supports research -- at NIH, throughout the United States, and worldwide -- to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at <http://www.niaid.nih.gov>.

The National Institutes of Health (NIH) -- The Nation's Medical Research Agency -- includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit <www.nih.gov>.

REFERENCE: K Ganeshan et al. Impairing oral tolerance promotes allergy and anaphylaxis: a new murine food allergy model. "Journal of Allergy and Clinical Immunology." DOI: 10.1016/j.jaci.2008.10.011 (2008).

##




© 2004-2008 by foodconsumer.org unless otherwise specified

Top of Page




Google
 
Web foodconsumer.org

Search Consumer-friendly Health Sites












We have moved to Food Consumer . Org



disclaimer | advertising | jobs | privacy | about us | newsletter | Submit news/articles
link partners: | Buy Viagra | MarketAmerica.com |
Buy a home | Auto Insurance | Mortgage refinancing | DaytonaCPA.com | Take Your Blog to a Higher Level
© Copyright 2004 - 2008 foodconsumer.org All rights reserved

Disclaimer: What's published on this website should be considered opinions of respective writers only and foodconsumer.org which has no political agenda nor commercial ambition may or may not endorse any opinion of any writer. No accuracy is guaranteed although writers are doing their best to provide accurate information only. The information on this website should not be construed as medical advice and should not be used to replace professional services provided by qualified or licensed health care workers. The site serves only as a platform for writers and readers to share knowledge, experience, and information from the scientific community, organizations, government agencies and individuals. Foodconsumer.org encourages readers who have had medical conditions to consult with licensed health care providers - conventional and or alternative medical practitioners.