Saturday Nov 29, 2008 (foodconsumer.org) -- Epidemiologic
studies showed that the association between body weight and breast cancer risk varied
depending upon the statuses of menopause and hormone receptors.
Suzuki and colleagues from Karolinska Institutet in
Stockholm, Sweden meta-analyzed data from studies published between Jan 1, 1970
and Dec 31, 2007 to examine the effect of body weight on breast cancer risk in
women with different statuses of menopause and hormone receptors.
Results from 9 cohorts and 22 case-control studies showed
that comparing the highest versus the reference categories of relative body
weight, the risk for estrogen receptor positive and progesterone receptor
positive (ER+PR+) breast cancer was 20 percent lower among premenopausal women,
but 82 percent higher among postmenopausal women.
The researchers also found that each 5-unit increase in
body mass index was correlated with a 33 percent increased risk of ER+PR+ breast
cancer among postmenopausal women and 10 percent reduced risk among
premenopausal women.
But no association was
observed for ER-PR- and ER+PR- tumors.
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