Improved body weight, diet quality, exercise and ability to function at conclusion of yearlong trial

PHILADELPHIA - A home-based program to improve exercise and diet led to significant, clinically meaningful improvement in body weight and physical function among older long-term cancer survivors in preliminary findings from the RENEW (Reach-out to ENhancE Wellness) trial, according to Wendy Demark-Wahnefried, Ph.D., from The University of Texas M. D. Anderson Cancer Center's Department of Behavioral Science. The data are being presented at the seventh annual American Association for Cancer Research Frontiers in Cancer Prevention Conference.

The trial, funded by the National Cancer Institute's Office of Cancer Survivorship, included 641 participants. All were 65 or older, had been diagnosed with breast, prostate or colorectal cancer at least five years prior with no evidence of recurrence, were overweight or obese, and had no medical conditions prohibiting moderate exercise.

"We know that when people are diagnosed with cancer they're at risk for comorbid conditions and functional decline," said Demark-Wahnefried. "For those 65 and over, data show they may become debilitated permanently, thus increasing health care costs and taking a toll on family members."

The participant group was divided into 319 who received an intervention and 322 who were waitlisted. Those in the intervention group participated in 15 telephone counseling sessions with a personal trainer throughout the intervention year, and worked toward establishing several daily goals, including: 1) performing lower body strength exercises; 2) walking 30 minutes; 3) using portion-control plates, cups and bowls; 4) consuming fewer than 10 percent of calories from saturated fat; and 5) eating more fruits and vegetables.

At the end of the year, the group showed improvements in their diet and exercise habits and improved physical function scores. Most significant were notable strength improvements in the participants' legs.

Individuals in the intervention group increased their physical activity to 44.9 minutes per week versus 29.7 minutes per week for the control group. Additionally, the intervention group saw a three percent drop in body weight versus a one percent drop in the control group.

"These findings are significant as the survivors who participated in the program had much better ability to stand-up, walk and function on their own, and enjoyed better quality of life," Demark-Wahnefried said "These functions are critical in retaining independence. The next step is to follow up with the participants to see if the effect is sustained, and replicate the results in the waitlisted group."

About M. D. Anderson
The University of Texas M. D. Anderson Cancer Center in Houston ranks as one of the world's most respected centers focused on cancer patient care, research, education and prevention. M. D. Anderson is one of only 41 Comprehensive Cancer Centers designated by the National Cancer Institute. For six of the past nine years, M. D. Anderson has ranked No. 1 in cancer care in "America's Best Hospitals," a survey published annually in U.S. News and World Report.