Thursday Nov. 20, 2008 (foodconsumer.org) -- Want to burn
Cut your intake of bad
A new study published in
the open-access journal PLoS ONE suggests that the so-called bad cholesterol or
low density lipoprotein inhibits the breakdown of fat in cells of peripheral
The study led by researchers from the Swedish medical
university Karolinska Institutet discovered a novel function of LDL as a
regulator of fat turnover besides its well-established detrimental effects in
From the study, Dr Johan Björkegren and colleagues found
LDL cholesterol slows the rate of fat breakdown (i.e. lipolysis) in adipocytes,
the peripheral cells responsible for fat storage.
Early studies have shown the fatty acids released from
the peripheral fat to the blood boost the synthesis of LDL precursors in the
liver. The current study seems to have proved that high levels of LDL could
inhibit the releasing fatty acids of the peripheral fat, a health observer
"The results of our study provide evidence of a
reciprocal link between the liver and peripheral fat regulating fat
turnover", says Dr Björkegren.
The finding of the study could suggest that lowering
cholesterol in the blood may also affect buildup of peripheral fat.
The study was conducted on cell cultures and tissue from
humans as well as in animal models with different levels of LDL. But how LDL
binds to the fat cells to inhibit the breakdown of the intracellular fat
remains to be researched, said project leaders Dr. Dr Josefin Skogsberg.
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