||Last Updated: Apr 20, 2011 - 9:38:09 AM
U.S. Department of Health and Human Services
NATIONAL INSTITUTES OF HEALTH NIH News
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) <http://www.niddk.nih.gov/>
Embargoed for Release: Wednesday, January 28, 2009, 5:00 p.m. EST
CONTACT: Arthur Stone, 301-496-3583 <e-mail: NIDDKMedia@mail.nih.gov>
WEIGHT LOSS IN OVERWEIGHT AND OBESE WOMEN REDUCES URINARY INCONTINENCE
Reducing urinary incontinence can now be added to the extensive list of
health benefits of weight loss, according to a clinical trial funded by
the National Institute of Diabetes and Digestive and Kidney Diseases
(NIDDK) and the Office of Research on Women's Health (ORWH), both part
of the National Institutes of Health (NIH). The paper reporting the
results of the trial will be published in the January 29 issue of the
New England Journal of Medicine.
The Program to Reduce Incontinence by Diet and Exercise (PRIDE),
conducted in Birmingham, Alabama, and Providence, Rhode Island,
recruited a total of 338 obese and overweight women who leaked urine at
least 10 times per week. The women were randomly assigned to either an
intensive six-month weight-loss program of diet, exercise and behavior
modification or to a group that received information about diet and
exercise, but no training to help them change habits.
The investigators report that women in the intensive weight-loss group
lost an average 8 percent of their body weight (about 17 pounds) and
reduced weekly urinary incontinence episodes by nearly one-half (47
percent). In contrast, women in the information-only group lost an
average 1.6 percent of body weight (about 3 pounds) and had 28 percent
"Clearly, weight loss can have a significant, positive impact on
urinary incontinence, a finding that may help motivate weight loss,
which has additional health benefits such as preventing type 2
diabetes," said NIDDK Director Griffin P. Rodgers, M.D.
Urinary incontinence affects more than 13 million women in the United
States and accounts for an estimated $20 billion in annual health care
costs, according to the paper. Obesity is an established and modifiable
risk factor for urinary incontinence, but conclusive evidence for a
beneficial effect of weight loss on urinary incontinence has been
lacking. The PRIDE trial provides evidence supporting weight loss as a
treatment for incontinence.
An important finding of the study is the difference between the two
groups in the reduction of incontinence. Among women in the weight-loss
group, 41 percent achieved a clinically relevant reduction of at least
70 percent of total incontinence episodes per week, whereas 22 percent
of women in the information-only group achieved the same level of
At six months, women in the weight-loss group were significantly more
satisfied with the change in their incontinence than were women in the
information-only group. This was assessed through self-reported
perceived change in frequency of incontinence, volume of urine loss,
the degree to which incontinence was a problem, and satisfaction with
the change in incontinence.
"Studies have documented that behavioral interventions help people lose
weight, which helps decrease the risk of developing type 2 diabetes and
high blood pressure, improve control of high blood pressure and
cholesterol levels, and enhance mood and quality of life," said Leslee
L. Subak, M.D., of the University of California, San Francisco (UCSF)
and lead author of the study. "Our results suggest that a decrease in
urinary incontinence is another health benefit associated with weight
loss and that weight reduction can be a first-line treatment in
overweight and obese women."
Co-authors on the PRIDE paper were Deborah Grady, M.D., M.P.H.,
professor of medicine at UCSF and the San Francisco Veterans Affairs
Medical Center; Rena Wing, Ph.D., of The Miriam Hospital and the Warren
Alpert Medical School of Brown University, Providence, R.I.; Delia
Smith West, Ph.D., of the University of Arkansas for Medical Sciences,
College of Public Health, Little Rock, Ark.; and Frank Franklin, M.D.,
Ph.D., of the University of Alabama at Birmingham.
Weight loss in PRIDE is comparable to that observed in the Diabetes
Prevention Program (DPP) and in the ongoing Action for Health in
Diabetes (Look AHEAD), two NIDDK-sponsored clinical trials in people
with type 2 diabetes. The PRIDE intensive weight-loss program was
modeled after these two trials.
For more information on PRIDE, go to <http://www.clinicaltrials.
gov/> and type NCT00091988 in the search window.
For information on the DPP and Look AHEAD trials, see <http://diabetes.niddk.nih.
>, and <http://www2.niddk.nih.gov/
More information on incontinence in women can be found at <http://kidney.niddk.nih.gov/
NIDDK, part of NIH, conducts and supports basic and clinical research
and research training on some of the most common, severe and disabling
conditions affecting Americans. The Institute's research interests
include: diabetes and other endocrine and metabolic diseases; digestive
diseases, nutrition, and obesity; and kidney, urologic and hematologic
diseases. For more information, visit <www.niddk.nih.gov>.
The ORWH (http://orwh.od.nih.gov/)
was established to serve as the focal point in the Office of the
Director for women's health research at the NIH. ORWH's mission is to
strengthen and enhance women's health research and sex/gender studies,
ensure that women are appropriately represented in biomedical and
biobehavioral research studies supported by NIH, and develop
opportunities for the advancement of women in biomedical careers and to
support career development for women and men in women's health research.
The National Institutes of Health (NIH) -- The Nation's Medical
Research Agency -- includes 27 Institutes and Centers and is a
component of the U.S. Department of Health and Human Services. It is
the primary federal agency for conducting and supporting basic,
clinical and translational medical research, and it investigates the
causes, treatments, and cures for both common and rare diseases. For
more information about NIH and its programs, visit <www.nih.gov>.
© 2004-2008 by foodconsumer.org unless otherwise specified
Top of Page
Search Consumer-friendly Health Sites