Foodconsumer.org

 
USCards.com Bookmark Us
All Food, Diet and Health News 
 
 Misc. News
 Must-Read News
 Letter to Editor
 Featured Products
 Recalls & Alerts
 Consumer Affair
 Non-food Things
 Health Tips
 Interesting Sites
 
 Diet & Health
 Heart & Blood
 Cancer
 Body Weight
 Children & Women
 General Health
 Nutrition
 
 Food & Health
 Food Chemicals
 Biological Agents
 Cooking & Packing
 Technologies
 Agri. & Environ.
 Laws & Politics
 
 General Health
 Drug News
 Diseases
 Mental Health
 Infectious Disease
 Environment
 Lifestyle
 Government
 Other News
 
 Food Consumer
 FC News & Others
Search





Search Foodconsumer & Others


Add to Google
Add to My Yahoo
Newsfeed

foodconsumer.org news feed
Su bmit news[release]



More than 100 credit cards available at uscards.com from uscards.com, you can pick more than 100 credit cards


General Health : Diseases Last Updated: Apr 20, 2011 - 9:38:09 AM


Variant gene linked to reduced colon cancer risk
By Sue Mueller
Oct 1, 2008 - 8:23:36 AM

E.mail t.his a.rticle
 P.rinter f.riendly p.age
Get n.ewsletter
 
   
Do you know vitami.n C lowers bloo.d pressur.e?


Wednesday October 1, 2008 (foodconsumer.org) -- U.S. researchers found a link between obesity and colon cancer risk, which could lead to development of a new test with greater accuracy for the disease.

The discovery may also provide some guideline as to how to effectively reduce the risk of developing colon cancer by following obesity-fighting activity like exercise, weight loss and health eating.

Some epidemiological studies have shown an association between adiposity and the risk of incident colorectal cancer.  But how obesity affects the risk of colon cancer is not well understood.

"While there is evidence of an association between circulating adiponectin levels and colorectal cancer risk, no association between genes of the adiponectin pathway and colorectal cancer have been reported to date," the authors wrote.

Boris Pasche, M.D., Ph.D. at the Comprehensive Cancer Center of at the University of Alabama at Birmingham (UAB) and colleagues found people with a common variant of the gene called ADIPPOQ have a 30 percent reduced risk of colon cancer compared to others.

ADIPOQ directs the production of a fat hormone called adiponectin, which is a protein hormone that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism.

For the study, Virginia G. Kaklamani, MD, D Sc, lead author, at the Feinberg School of Medicine, Northwestern University, Chicago and colleagues tested patients participating in two case-control studies to examine two genes the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and their association with colorectal cancer risk.

The first study involved 441 patients with colorectal cancer and 658 controls; both groups were of Ashkenazi Jewish ancestry and from New York while the second one included 199 patients with colorectal cancer and 199 controls from Chicago, matched 1:1 for sex, age and ethnicity.

From the first study, the researchers found the variant of the ADIPOQ gene rs266729 was associated with a 28 percent reduced risk of colorectal cancer while from the second study, the variant was linked to a 46 percent reduction in colorectal cancer risk.  Together, variant was associated with a 27 percent reduced risk.

The researchers wrote “If these exciting results can be confirmed in other studies, the adiponectin axis may emerge as an important modifier of colorectal cancer risk. Future studies will need to address the potential impact of adiponectin and its SNPs in the prognosis of colorectal cancer and also may be incorporated in genetic risk models for the disease.”

The study appears in the October 1 issue of JAMA, the Journal of the American Medical Association.

"Our hope is that we can significantly improve the screening and early detection for this disease, and open new avenues for better understanding the genetic and lifestyle factors that influence colon cancer risk," said Pasche.

Colon cancer is the third-leading cancer killer in the United States. The disease is expected to be diagnosed in 149,000 people and kill 50,000 each year, according to estimates from the American Cancer Society.

For more information on the study, read
http://jama.ama-assn.org/cgi/content/full/300/13/1523





© 2004-2008 by foodconsumer.org unless otherwise specified

Top of Page




Google
 
Web foodconsumer.org

Search Consumer-friendly Health Sites












We have moved to Food Consumer . Org



disclaimer | advertising | jobs | privacy | about us | newsletter | Submit news/articles
link partners: | Buy Viagra | MarketAmerica.com |
Buy a home | Auto Insurance | Mortgage refinancing | DaytonaCPA.com | Take Your Blog to a Higher Level
© Copyright 2004 - 2008 foodconsumer.org All rights reserved

Disclaimer: What's published on this website should be considered opinions of respective writers only and foodconsumer.org which has no political agenda nor commercial ambition may or may not endorse any opinion of any writer. No accuracy is guaranteed although writers are doing their best to provide accurate information only. The information on this website should not be construed as medical advice and should not be used to replace professional services provided by qualified or licensed health care workers. The site serves only as a platform for writers and readers to share knowledge, experience, and information from the scientific community, organizations, government agencies and individuals. Foodconsumer.org encourages readers who have had medical conditions to consult with licensed health care providers - conventional and or alternative medical practitioners.